抄録
Patients, who had suffered from cerebral thrombosis more than a month before and were in chronic state, were randomly divided into 2 groups. In group 1 they were first administered cinepazide malate for one month, which hardly inhibited platelet aggregation, and followed by an addition of a low dose of aspirin (50mg/day) for a further one month. In group 2 both drugs were administered in the reserve way; namely, at first the low dose of aspirin for one month and then cinepazide malate additively for a further one month. Platelet aggregability was checked by use of lumi-aggregometer and when the inhibitory effect on the aggregability was still inadequate, 50mg of aspirin were added every week untill the platelet aggregation decreased to the adequate level. A neurologist who was not informed about the trial schedule evaluated the clinical signs and symptoms of each patients in detail at the fixed intervals.
The results were as follows:
1) In most patients, platelet aggregability was adequately inhibited by a low dose of aspirin (50mg/day).
2) It was suggested that drugs improving cerebral circulation were clinically more useful if they had simultaneously the inhibitory effect on platelet aggregability.
