抄録
The particle size of HDL was measured in 68 diabetics, 42 patients with coronary heart disease (CHD), and 121 normal subjects by high performance liquid chromatography.
In 121 normal subjects there was a significant correlation between the particle size of HDL and the concentration of plasma HDL cholesterol (r=0.201, p<0.05), or the concentration of plasma triglyceride (r=-0.241, p<0.02). The particle size of HDL became smaller as the plasma triglyceride increased or the plasma HDL cholesterol decreased. The particle size of HDL did not correlate with the concentration of plasma cholesterol.
The mean concentration of plasma cholesterol and triglyceride was higher and the mean concentration plasma HDL cholesterol was lower in diabetics and patients with CHD than that in normal subjects. However the mean particle size of HDL in diabetics and patients with CHD was significantly larger than that in normal subjects. The mean particle size of HDL in male diabetics with normolipidemia (TC<220mg/dl and TG<150mg/dl) was also significantly larger than that in male normal subjects.
From these results it is suggested that the larger particle size of HDL is characteristic of dial etes or CHD, and related to the high incidence of CHD in diabetics.
