過酸化脂質と血液凝固に関する研究
1987 年 15 巻 3 号 p. 687-689
詳細
1987 年 15 巻 3 号 p. 687-689
Effects of lipid peroxides on antithrombin III (AT-III) and protein C in plasma were observed. Cumene hydroperoxide, tetraethoxypropane, arachidonic acid peroxide and linoleic acid hydroperoxide were used as lipid peroxides for experimental reagents. The chromogenic substrates were used for the measurements of AT-III and protein C. Following results were obtained.
1) Cumene hydroperoxide and tetraethoxypropane even in low dose reduced AT-III activity.
2) Arachidonic acid peroxide only in relative high dose reduced AT-III activity.
3) Linoleic acid hydroperoxide didn't reduce AT-III activity.
4) Cumene hydroperoxide, tetraethoxypropane and arachidonic acid peroxide didn't reduce protein C activity in same dose although they reduced AT-III activity.
