The Relationship between Ultrawatersoluble LDL (UWS-LDL) and Platelet Aggregability

Tsugumichi UEMURA; Takemichi KANAZAWA; Masahiro IZAWA; Hirohiko KANEKO; Kogo ONODERA; Hirobumi METOKI; Yoshito SHIMANAKA; Reiko KAWAHARA; Yasaburo OIKE

doi:10.5551/jat1973.15.3_767

Tsugumichi UEMURA, Takemichi KANAZAWA, Masahiro IZAWA, Hirohiko KANEKO, Kogo ONODERA, Hirobumi METOKI, Yoshito SHIMANAKA, Reiko KAWAHARA, Yasaburo OIKE

著者情報

キーワード: Native LDL, UWS-LDL, Platelet aggregability

ジャーナルオープンアクセス

1987 年 15 巻 3 号 p. 767-772

DOI https://doi.org/10.5551/jat1973.15.3_767

詳細

抄録

The effects of native LDL and UWS-LDL on the platelet aggregation induced by ADP, collagen, and epinephrine were investigated.
1) Native LDL inhibited slightly the platelet aggregation induced by ADP or collagen, but slightly enhanced it induced by epinephrine.
2) UWS-LDL enhanced markedly the platelet aggregation in these three aggregants.
3) UWS-LDL dialyzed against flowing water for 120 hours enhanced the platelet aggregation more than that for 48 hours.
It was speculated that the interaction between platelet and UWS-LDL plays a very important role in formation and progression of arteriosclerotic lesion.

責任著者(Corresponding author)

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