抄録
We report here a case of amyloidosis associated with hyper-α-lipoproteinemia. An 80-year-old man admitted to our University Hospital because of foot edema and general malaise. Laboratory examination revealed slight increase in transaminase (GOT 149, GPT 146IU/l), remarkable elevation of alkaline phosphatase (ALP, 1, 241IU/l), and elevation of high density lipoprotein (HDL)-cholesterol (182mg/dl) as well as total-cholesterol (390mg/dl).
From the 29th admission day to the 34th day HDL-cholesterol was decreased to 19mg/dl. Totalcholesterol maintained an elevated level. ALP, which had already been at high level on admission increased to 2, 369IU/l at day 30. Total bilirubin was also increased and attained the level of 25mg/dl at day 47, when the patient died of hepatic failure. Liver tissue specimens taken immediately after death showed severe atrophy of hepatocytes secondary to dense amyloid infiltration.
