Lipid Deposition in Aorta of Cholesterol-Fed Rabbits

-With Special Reference to the Relationship between the Area of Lipid Deposition and the Concentration of Serum Total Cholesterol-

Abstract

By feeding rabbits on diets containing 0, 0.1, 0.5 or 1.0% of cholesterol, the relationship between the levels of serum total cholesterol (TC) and lipid deposition in aortic surface was studied. Whereas the level of serum TC in 0.1% cholesterol-fed rabbits did not change from the basal level (about 30mg/dl), the level of serum TC in 0.5% cholesterol-fed rabbits increased to about 400mg/dl between 4 and 10 weeks after cholesterol-loading and that of serum TC in 1.0% cholesterol-fed rabbits increased continuously to a higher level. The extents of lipid deposition in aorta were related closely with the “integrated value” of TC, i. e. sum of the serum TC values obtained at each week.