Restenosis is one of important problems after PTCA and may be related to marked platelet accumulation at the dilatation site. The preventive effect of dilazep, which is well known as antiplatelet drug, on thrombus formation induced by transluminal dilatation in rabbits was investigated. The drug effect was evaluated histologically and semi-quantitatively using an image analysis system. The conclusion is summarized to be as follows;
1) Marked mural thrombus constituted largely from platelet aggregates and slightly from fibrin network was observed on the injured abdominal aorta one hour after dilatation.
2) Dilazep obviously inhibited this thrombus formation.
3) These results suggest that dilazep will be clinically useful for the prevention of restenosis after PTCA.
