Abstract
Probucol markedly reduces the LDL-C level in hyperlipidemic patients, but it also reduces HDL-C, which is believed to result in an anti-athero-sclerotic effect. In this study, factors useful for predicting the reduction in HDL-C by Probucol were examined in order to predict the problem before actual administration.
Probucol (250-750mg/dl) was administered to 30 patients with type II hypercholesterolemia. Among them, 23 patients showed 20% or greater decrease in the HDL-C level after administration. To evaluate the factors which permit identification of this group, linear discriminant function analysis was performed using 12 preadministration lipid levels. The analysis indicated that the Apo A-I/HDL-C ratio has the greatest predictive value (F=17.8, p<0.01) of all the parameters, and that the HDL-C level is reduced by 20% or more by Probucol administration when this ratio is 5.3 or less.
