Generation of Interleukin 1 at Inflammatory Sites: Kinetics and Producing Cells

抄録

Studies of an immune potentiation factor which was generated only during the early stage of inflammation lead us to conclude that this factor was mainly derived from exuded PMNs at the inflammatory site. The ultimately purified factor was identified as rabbit IL 1β. We assume that PMNs were triggered to express mRNA for both IL 1α and IL 1β shortly after exudation into the inflammatory site, although the expression of IL 1βmRNA was about 6 times greater than that of IL 1α. This may contribute in understanding the biologic function of IL 1 as an autacoid which acts only for a brief period during the early stage of the inflammation. Also, this result may give us an opportunity to propose a new concept of “neutrokine” as one of the mediators of inflammation.