We investigated the relationship between fatty liver and serum lipids using electrocardiogram (ECG) findings in patients with glucose intolerance.
The cases with glucose intolerance diagnosed by 75g OGTT were 40 to 65 years old. Fatty liver was determined by brightness through abdominal echography.
1. 1) 26 male cases with fatty liver and 59 cases without were 46.1±11.9 (M±SD) years old and 49.6±11 years old, respectively and 106.9 and 101.4% on an average in relative body weight ratio (RBWR). GPT and TG/HDL-C ratio increased significantly in cases with fatty liver as compared to cases without, while HDL-C decreased. 2) 9 female cases with fatty liver and 15 cases without were 52.9±9 years old and 56.7±4.1 years old, and 107.4% and 100.8% in RBWR. GPT and apo C-III increased significantly in cases with fatty liver. 3) 15 male cases with fatty liver and 47 cases without, who showed the normal ranges of serum transaminases, were 49±11 years old and 45±11 years old, and 110% and 100.7 in RBWR (p<0.005). HDL-C decreased significantly in cases with fatty liver, while atherogenic index, TG/HDL-C ratio and apo E increased. 4) In cases not given medical agents, there were significant positive correlations (r=0.53, 0.53, 0.71 or 0.52) between body weight changes and the changes of GPT, GOT, FBS or cholesterol. 5) There were significant positive correlations (r=0.75, 0.8 or 0.72) between carbohydrate intakes and GPT, GOT or γ-GTP in cases with fatty liver, while a significant negative correlation (r=-0.87) between protein intake and GOT.
2. Seven cases consisting of 5 males and 2 females, who resulted in the disappearance of the previous fatty liver during the period of 12.4±6.9 months, showed the significant decrements of serum cholesterol and LDL cholesterol.
3. 24 male cases with fatty liver and 26 cases without were 51.3±7.7 years old and 52.3±7.1 years old, and 119.9±13.5% and 117.1±6.8% in RBWR. The horizontal ST depression of resting ECG and the positive Master double exercise test were 20.8% and 4.8% respectively in cases with fatty liver, while 0% and 0% in cases without. From these findings, the cases with fatty liver tended to be accompanied with the increments of GPT, cholesterol, LDL-cholesterol, atherogenic index or RBWR or with the decrements of HDL-cholesterol, indicating the tendency of arteriosclerosis in fatty liver.
