抄録
Effects of β-adrenergic stimulants (β1 selective: denopamine; β2 selective: terbutaline) on serum lipoprotein metabolism were examined in 25 healthy men. Subjects were randomly allocated to a control group (n=8, placebo t.i.d.), a denopamine group (n=9, 10mg t.i.d.) and a terbutaline group (n=8, 4mg t.i.d.) and administered their respective agents for 14 days. Blood samples were obtained in the morning after an overnight fast. Following terbutaline administration, plasma cyclic-AMP levels significantly increased compared to placebo and denopamine groups. There were no significant differences between the three groups (placebo, denopamine, terbutaline) with respect blood pressure, pulse rate, total cholesterol, triglyceride, HDL cholesterol, HDL2, 3 cholesterol, apolipoproteins (A-I, A-II, B, E), FFA, fasting blood glucose, IRI, glucagon and serum electrolytes.
