Abstract
Serum Lp(a) lipoprotein [Lp(a)] levels in non-insulin dependent diabetics (NIDDM) were determined by a sensitive enzyme-linked immunosorbent assay (FLISA).
The Lp(a) concentration in NIDDM was significantly higher than in normal subjects. However, the Lp(a) was not correlated with fasting blood sugar (FBS), hemoglobin A1C (HbA1C) and the obesity index. The serum levels of TC, TG, LDL-C and Apo B significantly increased and those of HDL-C, Apo A-I and Apo A-II significantly decreased in NIDDM.
According to Hayashi's multidimensional quantification theory (type I analysis), a positive correlation was observed between the Lp(a) and diabetic retinopathy, but there was no correlation between the Lp(a) and diabetic nephropathy or nephropathy.
These results suggest that the Lp(a) plays some role in the development of diabetic retinopathy.
