抄録
Male New Zealand white rabbits were fed an atherogenic cholesterol diet (0.5% in diet) (Group I), the cholesterol diets containing pantethine (0.5% in diet) (Group II), soysterol (1.0% in diet) (Group III) and these 2 drugs (Group IV) for 8 weeks. Vitamin E was also added at a concentration of 0.17% to Group IV (Group V).
The combined treatment for hypercholesterolemia with 2 (Group IV) or 3 drugs (Group V) resulted in a marked reduction of (V)LDL-cholesterol together with serum cholesterol in about 30% of the control rabbits fed on the cholesterol diet, although the pantethine alone did not show a significant reduction of (V)LDL-cholesterol. Therefore, the hypocholesterolemic action of pantethine or soysterol was increased incrementally by the combined treatment of 2 or 3 drugs. The combined treatment also produced a marked decrease in the levels of apolipoproteins B and E.
A distinct reduction in the area of the atheromatous lesion of the intimal thickening was also observed in the aorta and coronary artery of the rabbits of Groups IV and V.
Fatty degeneration of the liver and spleen, glomerulitis and fat deposits in the interstitial tissue of the kidney were also inhibited by the reduction of serum cholesterol.
These findings, demonstrate that the combined treatment of pantethine, soysterol with vitamin E is the most effective method for improving serum lipoprotein disorders and for preventing the incidence of atheromatous lesions in the aorta and coronary artery in cholesterol-fed rabbits.
