Abstract
Effects of probucol administration (500mg/day for 12 weeks) on serum lipids, apolipoproteins and several parameters were studied in 17 patients with hypercholesterolemia, which consisted of type IIa-, IIb- and IV-hyperlipemia. Serum levels of total cholesterol and triglyceride decreased in all types. Apolipoprotein Al and B decreased in type IIa and IIb. HDL cholesterol decreased in type IIa and IV. Significant decreases in HDL cholesterol/apolipoprotein A1 ratio and LDL cholesterol/apolipoprotein B ratio were seen only in type IIa. In type ha, it appears that probucol decreases the particle number of lipoproteins such as HDL and LDL which is abnormally high by nature, and also decreases their cholesterol contents.
