コレステロール負荷ウサギの交感神経ならびに副腎機能におよぼすたばこ煙吸入の影響

抄録

In order to study the mechanism of the development of atherosclerosis in response to a cholesterol (CH) diet and smoking (SM) with reference to the function of the sympathetic nervous and adrenal systems, male rabbits fed a CH-supplemented (1.5%) diet and inhaled standard (SM-1) or nicotineless cigarette (SM-2) twice a day for 12 weeks.
A marked deposit of lipids was noted in the aorta of animals fed a CH diet, with increased CH in the plasma, liver and adrenal glands. Anemia and decubital ulcer formation were also pronounced. No combined effect of additional SM loading on these findings was noted.
Plasma dopamine-β-hydroxylase (DβH) activity and the catecholamine contents of the heart and adrenal glands increased.
The increases in the adrenal glands weight and in the plasma corticoid level were more pronounced with SM, especially with SM-1 loading. Single loading of SM-1 and SM-2 also raised the levels of plasma DβH and the tissue catecholamine.