抄録
We have studied the effect of Nipuradilol (Nip), a nitro-based β-blocker, on the proliferative changes of cultured vascular smooth muscle cells (VSMC). Nip had a direct inhibitory effect on the proliferation of VSMC grown in the presence of 10% FCS through the substantial supression of DNA synthesis. This inhibitory effect of Nip was accompanied by an increase in the cyclic-GMP content of VSMC, but not by an inhibition of cellular Na+-H+ antiport. These results suggest that Nip directly inhibits VSMC proliferation, presumably via an activation of the cellular cyclic-GMP system.
