抄録
Remnant like particles (RLP) were studied in 859 healthy subjects (548 male and 311 female, 22 to 78 years old) who underwent medical examination. RLP are lipoproteins that are detected as unbound lipoproteins in human plasma by immunoaffinity mixed gels using monoclonal antibodies, anti-apoprotein A-I and anti-apoprotein B-100. RLP are composed of chylomicron and very low density lipoprotein remnants, which are known to be risk factors of atherosclerosis. The RLP-cholesterol level was significantly higher (p<0.001) in males (2.4±1.8mg/dl; mean±SD) than in females (1.7±1.4mg/dl) and tended to increase with age. The ratio of RLP-cholesterol/triglyceride increased with age and it was higher in males than in females. There was a positive relationship between serum triglyceride and RLP-cholesterol (r=0.82, p<0.001), but not between serum total cholesterol and RLP-cholesterol.
Even when these comparisons were made for subjects with normolipidemia (serum total cholesterol <220mg/dl and triglyceride<150mg/dl), the same tendency was observed.
