抄録
The Sansuiken-Lipid Intervention Trial (S-LIT) was an intervention study to assess: 1) the acceptability and long-term compliance for a management program for hypercholesterolemia (serum total cholesterol concentration, TC<220mg/dl) in Japanese male workers, ≥40 years old; and 2) the relationship between serum cholesterol (TC) levels and the onset of ischemic heart disease (IHD). This interim report compared the long-term (3 years) serum lipid profile in the three cohorts; drug (simvastatin) treatment group (DT), diet-intervention group (DI), and non-treatment group (NT), which were draum from 1, 143 workers with hypercholesterolemia, patients were assigned to groups according to their own perference, not by randomization. The DT group had the highest initial levels of TC, triglyceride (TG), and low-density lipoprotein cholesterol (LDL-c) among the 3 groups. However, The DT group demonstrated the most improvement in normalizing TC (DT=34.2%, DI=7.9%, and NT=11.4%), high density lipoprotein cholesterol (HDL-c) (DT=47.6%, DI=46.3%, and NT=23.8%) and LDL-c (DT=50.0%, DI=19.3%, and NT=13.8%). While there were no differences in normalizing serum triglyceride (TG) levels. The dietary therapy (DI group) did not Show any improvement in lipid parameters in the cases with mild hyperlipidemia; with initial values of TC>250mg/dl, TG>250mg/dl, HDL-c<35mg/dl, and LDL-c>180mg/dl. These results suggest the importance of drug treatment using simvastatin for Japanese male worker with mild hyper-cholesterolemia, accordind to their lipid profiles.
