抄録
Nicomol [2, 2, 6, 6-tetrakis (nicotinyloxymethyl)-cyclohexanol], a derivative of nicotinic acid, was given to 25 patients with hyperlipidemia of type IIa, IIb or IV at a level of 0.6-1.2g per day for 8-32 months. Facial flush, erythema and itching of the skin temporarily occurred as side effects in 11 patients. Lowering of the plasma cholesterol level more than 50mg/100ml was attained in 35-50% of the cases. Decreases in plasma triglyceride concentration were observed in almost all of the cases of type IIb and IV in which the triglyceride level before treatment was more than 150mg/100ml. However, in several cases in which the triglyceride level was previously normal, that is, in type IIa hyperlipidemia, plasma triglyceride showed a slight or moderate increase and there was a change in lipoprotein lectrophoretic pattern from type IIa to type IIb or IV.
In three cases of alcoholics (one female and two males) which presented type IIa or IIb hyperlipidemia before treatment, a sever hyperlipemia of type IV or V appeared during the course of the treatment. Prohibition of alcohol brought a prompt healing and the withdrawal of the drug also resulted in a recovery of plasma lipid level.
