Abstract
In our previous pathological study of the common carotid arteries of autopsy cases in various diseases, we conformed the fact that the sclerotic changes were stronger in following order, myocardial infaction, cerebrovascular diseases, diabetes mellitus and liver cirrhosis.
In this study, we selected 10 cases of cerebrovascular diseases, 10 cases of diabetes mellitus with vascular complication and 19 cases of liver cirrhosis. Then we compared of blood aggregation and fibrinolysis from the following items hepaplastin test (II, VII, X), platelet aggregation, platelet factor 3, platelet spreading test, serum phospholipid, plasma fibrinogen, fibrin and fibrinogen degradation products (FDP), plasminogen and antiplasmin activity (lysin sepharose affinity chromatography).
1) Hepaplastin test was 93.5±18.5% in the normal controls and elevated in the patients with arteriosclerotic groups, (cerebrovascular disease 137.0±19.0%, diabetes mellitus 105.5±15.5%) and decreased in the liver cirrhosis (60.0±9.3%).
2) Platelet aggregation increased in the patients with arteriosclerotic groups, (cerebrovascular disease 63.0±13.0%, diabetes mellitus 65.1±10.3%) but decreased in the liver cirrhosis (45.1±21.4%).
3) Platelet factor 3 level was in normal range, but highest in the diabetes mellitus (86.8±27.7%) and lower in the liver cirrhosis (41.5±20, 0%) and diabetes mellitus (36.7±10.0%). Phospholipid contents in serum, which had a correlation with platelet factor 3, was higher then diabetes mellitus (248±73mg/dl) than other two groups.
4) Fibrinogen level in plasma was 188±11.3mg/dl in the normal controls and elevated in the patients with cerebrovascular disease (305±125.0mg/dl) and diabetes mellitus (281.9±56.2mg/dl).
5) Fibrinolytic activity, considered from FDP, Plasminogen and antiplasmin was elevated in the all three groups. From these findings, local f ibrinolysis was suggested in the case of cerebrovascular diseases and diabetes mellitus.
6) Platelet mosphological study by means of platelet spreading test showed differences among these three groups.
These finding from the stand point of blood aggregation and f ibrinolysis were compatible with previous pathological findings.
