Abstract
The significance of thrombus formation in atherogenesis was experimentally studied. The mural white thrombus on the aorta of rabbits induced by insertion of polyethylene tubing was subsequently organized by modified smooth muscle cells and incorporated into the aortic intima, resulting in the localized fibrous thickening of the intima similar to “fibrous plaque” seen in man. Some of these lesions further developed the atherosclerotic lesions resembling “atheroma” found in man without any cholesterol feeding.
A combination of cholesterol feeding with this experimental model enhanced the lipid deposition into the lesion. Degree of lipid depositions correlated closely with the level of serum cholesterol.
