抄録
Such hypolipemic agents as Nicomol, 1-1-bis-(4′-(1″-carboxy-1″-methylpropoxy) phenyl) cyclohexane (S-8527) and Oxandreolone were administered for 16 weeks to 56 outpatients with hypertension and/or diabetes mellitus.
The blood was taken 2 weeks before and just before the treatment, and on 2nd, 4th, 8th, 12th and 16th week after the treatment.
1) There is an obvious difference of the effects among Nicomol, S-8527 and Oxandrolone, from the viewpoints of both serum lipids and glycoproteins.
2) Free fatty acid (FFA), β-lipoprotein (β-LP) and total cholesterol (TC) were decreased in the serum by Nicomol administration; triglyceride (TG), β-LP and TC were decreased also by S-8527 administration; phospholipid (PL), TC, TG and β-LP were decreased also by Oxandrolone administration.
3) Serum glycoproteins were obviously decreased by Nicomol or S-8527 administration, though increased by Oxandrolone administration.
4) These 3 agents, usually understood as hypolipemic and effective for arteriosclerosis as a whole, must be used in consideration of the characteristic effects of each agent on both serum lipids and glycoproteins.
