Abstract
The purpose of this report is to observe the detail of platelet aggregation in case of maximum aggregation induced by usual ADP concentration. It was recorded two aggregation curves induced by high (10-5) and low (0.2×10-5) concentrations of ADP in same platelet rich plasma, and classified them into four types. Dissociation after aggregation was found by both ADP in 95% of normal, and this normal pattern classified into types I and II. Type III consisted of case that had the difference of more than 40% between aggregation rates after three minutes obtained by both inducer. Type IV consisted of no dissociation observed by both inducer.
In diabetics, the percentage of types I and II as normal pattern decreased to 70.5% compared with 95% in normal, type III increased to 20.5% compared with 5% in normal and type IV present at 9.1%. Only 46.2% in group with retinopathy belonged to normal type, 25.6% to type III and 28.2% to type IV. According to the progress of retinopathy, the percentage in group with increased platelet aggregation rose significantly. With complacation of macroangiopathy, type IV that showed maximum platelet aggregation increased to 20.5% as normal type decreased to 40%.
Transformation of platelet aggregation pattern was observed after a week aspirin ingestion of 1.5g. In type IV, 8 of 10 cases remained unchangeable and others transformed into type III after ingestion. In type III, 13 of 15 cases improved and others remained unchangeable. In type II, 8 of 12 cases transformed into type I. It was found that aspirin was effective for moderatly increased platelet aggregation.
Although platelet aggregation of acute myocardial infarction showed normal pattern immediately after attack, they began to increase in many cases 2 days later and lasting for 10 days.
As above, new classification was made on platelet aggregation pattern that obtained from inducing by both of high and low concentrations of ADP and its clinical significance was studied.
