1978 Volume 6 Issue 1 Pages 21-25
Studies were carried out on the pathogenesis of hyperlipidemia from angles of the roles of insulin and glucagon in plasma, and the results are obtained as follows:
1) Basal plasma insulin (IRI) levels were higher in subjects with the hyperlipidemia of type IIb, IV and V than in normolipidemic subjects. However, there were hardly any difference of plasma glucagon (IRG) levels between normolipidemic subjects and those with hyperlipidemia.
2) The increase of the plasma IRI levels after 50g GTT or after arginine loading test was higher in hypertriglyceridemic subjects with normal glucose tolerance than in normal controls, but it was lower in hypertriglyceridemic subjects with abnormal glucose tolerance than in normal controls.
3) There were no significant difference of patterns of IRG levels after 50g GTT or after arginine loading test among normal controls, hypertriglyceridemic subjects with normal glucose tolerance, and hypertriglyceridemic subjects with abnormal glucose tolerance.
4) These observations suggest that the cause of increase of serum pre-β lipoprotein may differ between subjects with normal glucose tolerance and those with abnormal glucose tolerance.
