1978 Volume 6 Issue 1 Pages 13-19
Progress in our knowledge of the lipoprotein metabolism has generated increasing evidence that atherosclerosis may be related not only to the beta- and pre-beta-lipoproteins but also, in particular, to chylomicron or remnants of chylomicron.
There are acute changes of serum lipids and/or lipoproteins during the day, and obviously the degree and duration of alimentary lipemia are more severe and persistent when compared with that in the fasting state. The clinical study was undertaken to detect the dietary lipemia.
For this purpose, a butter loading diet composed of two eggs, the yolk of three eggs and fifty grams of butter was ingested by the subjects, and the concentration of serum lipids and lipoproteins was determined at two-hour intervals. The feeding of the diet containing a large amount of long chain saturated and monounsaturated fatty acids produced marked hyperlipidemias and hyperlipoproteinemias in all subjects.
However, the increment of both lipids and lipoproteins accepted as major risk factors for atherogenesis was more considerable in the atherosclerotic and/or hypertensive subjects than in the young normal subjects. In the atherosclerotics, the relative increments of long chain saturated and monounsaturated (oleic) fatty acids were observed in the fourth hour when the concentrations of serum triglyceride, cholesterol as well as beta- and pre-beta-lipoproteins reached maximum levels after the butter loading.
Similar changes of serum lipids (eccepting the free fatty acid as well as total fatty acid composition) and lipoproteins were induced by a fructose loading diet containing two eggs, the yolk of three eggs, ten grams of butter and ninty grams of fructose.
According to the recent concept of serum lipid and its relevance to atherosclerosis, it was concluded that the acute dietary changes in serum lipids and/or lipoproteins might have an essential role in the pathogenesis of atherosclerosis and its clinical consequence.
