1978 Volume 6 Issue 1 Pages 9-12
Lipids of plasma, erythrocyte and arterial wall in patients with occlusive arterial diseases of the extremity were measured and analyzed in detail. The following results were obtained.
1. There were found no differences in plasma lipids lvels as cholesterol and triglyceride between patients with thromboangitis obliterans (TAO) and arteriosclerosis obliterans (ASO), althought level of triglyceride is usually higher than cholesterol.
There were found no correlation between plasma lipids level and both diseases in contrast to myocardial infarction.
2. Level of lipoperoxides was significantly raised in ASO compared to normal, although there was found no difference between TAO and normal.
3. Incidence of hyperlipoproteinemia was higher in ASO with occlusive lesion of central artery than with distal occlusion. Type IIa and b were frequently found in ASO with aorto-iliac occlusion.
4. Hyperlipoproteinemia was found more frequently in TAO than in ASO.
5. The pattern of fatty acid composition of plasma lipids was same in both TAO and ASO, although changes were more significant in ASO. 6.
There was no marked changes in lipids of erythrocyte membrane in both diseases.
7. Cholesterol, especially cholesteryl ester, was markedly increased in arterial wall in ASO. Phospholipids was also increased, although low in percentage compared to other lipids.
8. Increase of phospholipids in arterial wall was mainly resulted from increase of sphingomyelin, while phosphatidylethanolamine, phosphatidylserin and phosphatidylinositol were markedly decreased.
9. Fatty acid composition of cholesteryl ester in arterial wall was similar to that of plasma in ASO, suggesting of their origin from plasma. However, fatty acid composition of phospholipids was definitely different with that of plasma, suggesting of their synthesis in arterial wall.
10. Composition of phospholipids and total lipids in arterial wall in TAO was similar to those in normal artery, suggesting of its different nature of occlusive lesion in ASO.
