Relation between Serum Lipid and Lipoprotein Levels and the Degree of Coronary Artery Sclerosis Studies by Selective Coronary Cine-Angiography

Abstract

Selective coronary cine-angiography is a standard method for the assessment of the degree of coronary artery stenosis. This study was undertaken to evaluate the association between serum lipid and lipoprotein levels, and the degree of coronary artery disease (CAD) in 110 patients studied by selective coronary cine-angiography. Coronary atherosclerosis were assessed by signs of narrowing of caliber exceeding 25% or more in at least one of the three main branches of coronary arteries. All the patients were devided into four groups depending on the number of coronary artery involved. There was no significant difference among these groups with regard to age, sex, obesity, glucose intolerance, hypertension and smoking. The results were as follows:
1) The mean serum cholesterol levels in the groups with CAD were significantly higher than that in the group without CAD, and the higher the serum cholesterol level was, the more the number of involved coronary vessels increased.
2) The mean serum triglyceride levels in the groups with two and three involved vessels were significantly higher than that in the group without CAD, and the higher the serum triglyceride level was, the more the number of involved coronary vessels increased.
3) In the group with involved three vessels, the concentrations of serum cholesterol and triglyceride were the highest of all the groups.
4) The mean VLDL-cholesterol levels were significantly higher in the groups with two and three involved vessels than that in the group without CAD and the mean VLDL-triglyceride levels were significantly higher in the group with involved three vessels than that in the group without CAD.
5) The mean IDL-cholesterol levels were significantly higher in the groups two and three involved vessels, but there were no significant differences in the mean IDL-triglyceride levels among these groups.
6) The mean LDL-cholesterol and LDL-triglyceride levels in the groups with CAD were significantly higher than that in the group without CAD.
7) In the group with three involved vessels, the concentrations of cholesterol in VLDL, IDL and LDL fractions were the highest of all the groups.
8) The ratio of HDL-cholesterol to serum cholesterol was significantly lower in the groups with two and three involved vessels than that in the group without CAD.
9) HDL-phospholipid levels were significantly lower in the groups with two and three involved vessels, and the ratio of HDL-phospholipid to serum phospholipid was significantly lower in the all groups with CAD than that in the group without CAD.