1979 Volume 6 Issue 4 Pages 459-466
Serum low density lipoprotein (LDL) and very low density lipoprotein (VLDL) levels of 254 patients with cerebrovascular disease and 215 cotrols were determined by the heparin-Ca++ precipitation method. Serum high density lipoprotein-cholesterol (HDL-C) concentrations in the supernatant of heparin-Ca++-precipitated serum were also measured.
Serum LDL concentrations of healthy controls, who had no abnormalities in physical findings, blood pressure, urinalysis, ECG findings, etc., in-creased with age in female subjects. In male controls, the value in fourties was highest. The average values of healthy men and women under 39 years old were 424±170.2mg/dl and 377±130.6mg/dl, respectively. Serum VLDL concentrations were unaffected by age, and average values of male and female controls under 39 were 113±114.1mg/dl and 52±35.5mg/dl, respectively. Serum HDL-C concentrations increased with advancing age in male controls but were unaffected by age in female controls. The average HDL-C values of healthy men and women under 39 were 57±16.9mg/dl and 63±16.5mg/dl, respectively. In the obese subjects aged from 40 to 59, serum VLDL value was higher and HDL-C was lower than the values in age-matched healthy controls.
Average serum LDL value of the patients passed more than one year from stroke was higher than that of those within one year. Therefore to eliminate the possible influence of time after stroke on serum lipid profile, patients passed more than one year from onset were excluded. Average serum LDL and VLDL values of 89 patients with cerebral infarction were 574±162.8mg/dl and 159±100.9mg/dl, respectively, and the values of 34 patients with cerebral hemorrhage were 460±124.3mg/dl and 123±79.1mg/dl, respectively. Serum LDL value of patients with infarction was significantly higher than those of patients with hemorrhage and healthy controls. Serum VLDL levels of both patients were significantly higher than control value. Average serum HDL-C value of 123 cerebrovascular patients was 57±16.8mg/dl and it was significantly lower than control value. There was no difference between the values of two types of diseases.
These results may suggest the close association of abnormal lipid metabolism with cerebrovascular disease. Further investigation considering many factors should be necessary and it may contribute to the elucidation of the role of lipid metabolism in cerebrovascular disease that is not evaluated simply by the measurements of serum cholesterol or triglyceride levels.
