High Density Lipoprotein (α Lipoprotein) In Ischemic Heart Disease

Abstract

Quantitative analysis of HDL, LDL, VLDL, cholesterol and triglyceride in sera were carried out in patients with ischemic heart disease. In addition, analysis of serum lipoprotein by polyacrylamide gel disc electrophoresis was performed in the same subjects. The concentration of serum HDL was measured by rocket immunoelectrophoresis using an anti-α₁-lipoprotein-serum (BEHRINGWERKE AG) and that of serum LDL, VLDL was determined by precipitating method.
Subjects consisted of 51 patients with ischemic heart disease and 42 healthy men and women. Cases with ischemic heart disease were classified into groups of old myocardial infarction, acute myocardial infarction, angina pectoris and arrhythmia, i.e., atrial fibrillation and/or A-V block.
Mean values of serum HDL were lower in each group of ischemic heart disease than in the healthy group. Mean levels of serum cholesterol were significantly higher in each group of ischemic heart disease than in the healthy group, but each mean level was under 200mg/dl. There were no significant differences of the mean levels of serum triglyceride, LDL and VLDL between both groups. In polyacrylamide gel disc electrophoresis, the midband appeared more frequently in each group of ischemic heart disease than in the healthy group.
Results of our study suggest that low level of serum HDL play an important role in the development of ischemic heart disease. Frequent occurrence of the midband in patients with ischemic heart disease suggests another abnormal lipid metabolisms in these patients.
In addition, the consistence of the result of lipid analysis in the group of arrhythmia with those in the groups of myocardial infarction and angina pectoris is notable.