Acid Mucopolysaccharides in Aorta of Rats with Experimental Hypertension

Abstract

Acid mucopolysaccharides (AMPS) contents in aorta of rats with experimental hypertension (two-kidney and one-kidney types of Goldblatt hypertension and DOCA-salt hypertension) were increased significantly with blood pressure elevation.
AMPS contents were decreased with blood pressure fall by the antihypertensive treatment (hydrochlorothiazide, reserpine and hydralazine), while plasma renin activity and plasma noradrenaline levels were rather increased by the antihypertensive treatment.
Changes in composition of AMPS were mainly induced by sulfated AMPS (mono-and highlysulfated AMPS).
These results suggest that blood pressure affects on AMPS contents in the blood vessels in hypertension and this mechanism might play a role in the progression of atherosclerosis in hypertension.