1979 年 7 巻 2 号 p. 407-415
Trapidil inhibited: TXA2-induced platelet aggregation in rabbits, TXA2-induced constriction of excised strips of rabbit aorta, synthesis of TXA2 in platelets, TXA2-induced ischemic changes of heart of rabbits and increase in TXA2 synthesis after high cholesterol feeding in rats.
The above results show that trapidil posseses inhibitory action of TXA2 synthesis and antagonistic actions on TXA2, in addition to coronary dilating action.