抄録
Hypocholesterolemic effects of ML-236B, a potent inhibitor of cholesterol synthesis, have been studied in several animal species. In rodents like mice, rats and hamsters, this drug produced no detectable changes in serum cholesterol levels at doese as high as 500-2, 000mg/kg. On the other hand, hypocholesterolemic effects were obtained in hens, rabbits, dogs, monkeys and man at levels of 1-50mg/kg. The lack of effectiveness in the rat was shown to be, at least. partly, explained by the unexpected results that levels of hepatic 3-hydroxy-3-methylglutaryl-CoA reductase activity were extremely elevated in this species by the treatment with ML-236B while the excretion of fecal bile acids was markedly reduced.
