経口血糖降下剤の atherogenicity
1980 年 7 巻 4 号 p. 729-733
詳細
1980 年 7 巻 4 号 p. 729-733
The study was performed on 12 male rabbits, being devided into two groups; one group of 7 rabbits fed on the commercial rabbit pellet to which 2mg of Glibenclamide per kilo of the food was mixed (G-group), and the other of 5 rabbits fed on the rabbit pellet only as a control group (C-group). The food intake was limited to 200g daily.
Three months later, blood was collected from these rabbits in the fasting state for lipoprotein analysis, and then the aorta was taken out for determination of cholesterol and cholesterolester. Cholesterol content in the aorta of G-group (2.68±0.12mg/g wet weight) was significantly higher (p<0.05) than that of C-group (2.28±0.12mg/g wet weight).
The high density lipoprotein cholesterol level was similar in both groups, while the low density lipoprotein cholesterol level of G-group (10.8±2.3mg/dl) was higher than that of C-group (7.3±1.5mg/dl).
As a result of this study, it is suggested that Glibenclami de may have atherogenic action in the normal rabbit, probably because of an increment of low density lipoprotein cholesterol.
