Abstract
The catabolism of plasma triglyceride is regulated by lipoprotein lipase and lipoprotein lipase activator. Lipoprotein lipase activator was measured by a method which was based on the observation that guinea pig postheparin plasma would not hydrolyze triglyceride unless human serum (or any activator) was added. Plasma lipoprotein lipase activity, lipoprotein lipase activator, triglyceride and cholesterol were measured in 11 patients with type IV hyperlipidemia, 9 normolipidemic males and 10 normolipidemic females. All of them had neither drinking habit, obesity nor liver dysfunction. Lipoprotein lipase activity was selectively measured by an immunochemical method and was within normal limits in all subjects. Activator was significantly higher in type IV hyperlipidemic subjects (229±116%, mean±S. D.) than in normal subjects (male: 129±37, female: 92±18%)(p<0.05), and, as plasma triglyceride concentrations increase, activator (s) tends to increase. However, plasma triglyceride concentrations inversely correlated with activator/triglyceride (p<0.001), and in addition, inversely correlated with lipoprotein lipase activity/activator (p<0.001)
Further studies are necessary to understand the role of lipoprotein lipase activator for the genesis of the hypertriglyceridemia.
