抄録
Our previous report showed that when experimental rats were subjected to arteriosclerosis by artificially raising the cholesterol contents of their food-intake. 45Ca deposits were found on the aorta.
This study was undertaken to discover if 45Ca deposits can be prevented from forming (Experiment A) or removed once presents, in the aorta of rats suffering from arteriosclerosis (Experiment B), by the use of such known antiarteriosclerotic drugs as vitamin E, clofibrate and elastase, which each have a biochemically different function.
Elastase was found to prevent the formation of 45Ca deposits and the accumulation of the cholesterol in the aorta of the rats. In the case of vitamin E and clofibrate, their influence on the 45Ca and cholesterol was minimal more furthermore elastase, which was shown to have the most effect in preventing the formation of 45Ca deposits, was also used successfully to remove 45Ca deposits which had already formed in the aorta of the rats. In both the experiments using elastase, the elastin contents of the aorta were found to increase, whereas there was not marked change in the elastin contents when using vitamin E or clofibrate.
