Effects of γ-oryzanol on the serum HDL, LDL and total cholesterol (ch) and Triglyceride were studied in 17 cases whose age was 47 years old to 82 years old (mean age was 71.2 years old). Three hundred mg/day of γ-oryzanol was given for 4 months.
Serum HDL-ch was 50.0±2.3 (m±SE) mg/dl before γ-oryzanol and 53.7mg/dl 3 months later but HDL-ch which was below 50mg/dl before treatment increased significantly (p<0.01) from 43.3mg/dl to 50.4mg/dl 2 months later. HDL-ch below 45mg/dl increased significantly (p<0.01) from 41.3mg/dl (mean) to 50.0mg/dl (mean) 2 months later. LDL-ch decreased significantly (p<0.01) from 158.8mg/dl to 134.8mg/dl after γ-oryzanol. HDL-ch×10/LDL-ch showed significant changes (p<0.01) (from 3.26 to 4.14) 2 months later. Total-ch did not change and between 203mg/dl and 208mg/dl. Triglyceride did not show significant changes.
It is suggested that γ-oryzanol alters the metabolism of HDL-ch and LDL-ch and increases serum low HDL-ch.
