Journal of Atherosclerosis and Thrombosis
Online ISSN : 1880-3873
Print ISSN : 1340-3478
ISSN-L : 1340-3478
Involvement of von Willebrand Factor and PGI2 in Platelet Binding to a Partially Denuded Endothelial Monolayer
Hirotaka KuniiYasuko YagyuYukio MaruyamaTsuneo ImanakaTatsuya Takano
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1995 年 2 巻 1 号 p. 37-40

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Platelet binding to an endothelial monolayer was examined after denudation. The binding increased for up to 10 min and thereafter declined gradually. Antibodies against von Willebrand factor (vWF) inhibited the binding. Production of prostacyclin (PGI2) occurred 10 min after endothelial denudation. This study suggests that vWF is involved in the binding during the first 10 min and that PGI2 suppresses the binding thereafter. J Atheroscler Thromb, 1995 ; 2 : 37-40.
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