Breast Cancer
Online ISSN : 1880-4233
Print ISSN : 1340-6868
ISSN-L : 1340-6868
Review Articles
Gene Therapy for Breast Cancer. –Review of Clinical Gene Therapy Trials for Breast Cancer and MDR1 Gene Therapy Trial in Cancer Institute Hospital
Shunji TakahashiYoshinori ItoKiyohiko HatakeYoshikazu Sugimoto
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2006 年 13 巻 1 号 p. 8-15

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Gene therapy for advanced breast cancer is anticipated to be a useful therapeutic approach. Strategies in ongoing clinical protocols can be divided into four groups:(1)suppression of oncogenes or transfer of tumor-suppressor genes;(2)enhancement of immunological response;(3)transfer of suicide genes;(4)protection of bone marrow using drug resistance genes. We have started a clinical study of multidrug resistance(MDR1)gene therapy. Advanced breast cancer patients received high dose chemotherapy and autologous peripheral blood stem cell transplantation(PBSCT)with MDR1-transduced hematopoietic cells, and then were treated with docetaxel. Two patients have been treated so far, and in vivo enrichment of MDR1-transduced cells with docetaxel treatment has been seen. Both patients are in complete remission and had no apparent adverse effects from the MDR1 gene transfer.
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© 2006 by The Japanese Breast Cancer Society
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