Effect of Nasal CPAP Therapy on a Case of Obstructive Sleep Apnea Syndrome with Pulmonary Hypertension

Norihiko Hata; Noriaki Takahashi; Yasushi Oshima; Iwao Sasaki; Keiji Kurashina; Kenzo Otsuka; Takayuki Yoshizawa; Naoki Akamine; Tsuneto Akashiba; Yoshifumi Hosokawa; Takashi Horie

doi:10.2468/jbes.41.315

Norihiko Hata, Noriaki Takahashi, Yasushi Oshima, Iwao Sasaki, Keiji Kurashina, Kenzo Otsuka, Takayuki Yoshizawa, Naoki Akamine, Tsuneto Akashiba, Yoshifumi Hosokawa, Takashi Horie

Author information

Norihiko Hata
The First Department of Internal Medicine, Nihon University School of Medicine
Noriaki Takahashi
The First Department of Internal Medicine, Nihon University School of Medicine
Yasushi Oshima
The First Department of Internal Medicine, Nihon University School of Medicine
Iwao Sasaki
The First Department of Internal Medicine, Nihon University School of Medicine
Keiji Kurashina
The First Department of Internal Medicine, Nihon University School of Medicine
Kenzo Otsuka
The First Department of Internal Medicine, Nihon University School of Medicine
Takayuki Yoshizawa
The First Department of Internal Medicine, Nihon University School of Medicine
Naoki Akamine
The First Department of Internal Medicine, Nihon University School of Medicine
Tsuneto Akashiba
The First Department of Internal Medicine, Nihon University School of Medicine
Yoshifumi Hosokawa
The First Department of Internal Medicine, Nihon University School of Medicine
Takashi Horie
The First Department of Internal Medicine, Nihon University School of Medicine

Keywords: obstructive sleep apnea syndrome, nasal CPAP therapy, polysomnographic study, pulmonary hypertension

JOURNAL FREE ACCESS

1990 Volume 41 Issue 4 Pages 315-320

DOI https://doi.org/10.2468/jbes.41.315

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Abstract

A 32-year-old male patient was admitted to our hospital with complaints of snoring and excess of daytime sleepiness. On the basis of overnight polysomnographic study, this patient was diagnosed as obstructive sleep apnea syndrome (OSA). Right heart catheterization revealed a slight elevation of mean pulmonary arterial pressure (24 torr) on admisson.
Nasal CPAP therapy during sleep was started without discomfort and was continued for 3 weeks. During the course of nasal CPAP therapy, apnea index reduced from 59.2/hour to 1.3/hour and his complaints improved significantly. After 3 weeks therapy, day time PaO2 at rest markedly increased from 66.9 torr to 87.6 torr and mean pulmonary arterial pressure reduced from 24 torr to 18 torr. We may conclude that the nasal CPAP is an effective and non-invasive tool for the treatment of OSA.

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