2020 Volume 22 Issue 1 Pages 31-46
Human immunodeficiency virus type 1 (HIV-1) infection progresses to acquired immunodeficiency syndrome (AIDS), destroying the immune systems protecting humans from infections and malignant tumors over the years. Recently many types of anti-HIV-1 drugs that can prevent the infection from progressing to AIDS have been prescribed to HIV-1 infected individuals. Rapid and mutant-prone replication during HIV-1 infection causes quasispecies (populations of closely related virus variants), which is considered to contribute to escape from the immune systems and drug resistance. In this paper, a new quasi-steady state multiscale model of HIV-1 infection is presented. The model can exhibit the evolutionary dynamics of quasispecies better than a previous multiscale model by the author. Quasi-steady state, used in enzyme kinetics, is considered to be useful for modeling viral infection.
