抄録
Five wemen with postmenopausal osteoporosis were treated with 1α-OH-D3 for the period eight to twelve months.
Before and after the treatment iliac bone biopsies were performed. Undecalified 5μm thick section of the biopsy specimens were histomorphometrically compared with the normal.
Serum calcium, phosphorus and alkaline phosphatase were also examined.
The results were as follows;
1. In a case with normal level of serum calcium and phosphoruse, but with slightly high level of serum alkaline phosphatase, pretreatment-biopsy specimen showed osteoporomalacia histomorphometrically.
2. Io two cases with normal level of serum calcium, phosphorus and alkaline phosphatase specimens revealed osteoporomalacia.
3. Aftertreatment-biopsy showed improvement of osteomalacic factors in these three cases.
4. Other two cases with low turnover in remodelling, but without osteomalacia before the treatment, showed increased turnover rate after the treatment. Although one of these two cases showed an increase in bone mass, but the other case showed further decrease.
