腎不全ラットの骨病変に対する1α,25(OH)2vit. D3剤の効果
1984 年 2 巻 1 号 p. 78-87
詳細
1984 年 2 巻 1 号 p. 78-87
The experimental renal failure was made by the method of 5/6 nephlectomy in adult male rats. 1α, 25(OH)2vit.D3 and 1α(OH)vit.D3 at the dose of 0.05, 0.1, 0.2μg/kg were administered to these rats for 7 weeks. And the effects were evaluated by blood chemistry, urinanalysis and bone histomorphometry.
At the beginning of drug administration, i.e. 6 months after the nephrectomy, renal failure with bone change was evident. After administration of these agents, serum Ca showed increase and PTH revealed slight decrease but Al-P was still elevated. Bone histomorphometry showed significant decrease of resorption surface, number of osteoclast and volume of fibrous tissue. On the contrary tetracycline labeling rate and mineral appositional rate showed decrease, so osteoid was still abundant in some cases. No significant difference was observed between two drugs or among the doses.
