2016 Volume 56 Issue 8 Pages 109-115
Objectives: We examined the preventive effect of edaravone injection before aortic clamping for spinal cord ischemia in a rabbit model. Methods: The 13 rabbits were divided into three groups. In Sham group (S group) rabbits, the aorta was not clamped (n=3). In normal saline group (N group) rabbits, normal saline was injected just before aortic clamping, and the clamping time was 25 minutes (n=5). In Edaravone group (E group) rabbits, edaravone (3 mg/kg) was injected just before aortic clamping, and the clamping time was 25 minutes (n=5). The modified Tarlov score was evaluated after 24 hours, 48 hours and 7 days. Histopathological evaluation was performed on the specimen of the spinal cord. Results: The modified Tarlov’s score was tended to be higher in S group than in N group, and was similar in S group and in E group at each measuring point. Histopathological evaluation revealed more serious neuropathy in N group than in E group, but no significant difference was noted between S group and E group. Conclusions: Preventive injection of edaravone before aortic clamping might be effective for spinal cord ischemia in a rabbit model.
