Role of NLRP3 Inflammasome in Atherosclerosis and Aortic Aneurysm

Abstract

The importance of sterile inflammation has been shown in the pathogenesis of cardiovascular diseases, such as atherosclerosis and myocardial infarction. We have reported that NLRP3 inflammasome plays a crucial role in the development of atherosclerosis and abdominal aortic aneurysm using mouse models. Recently, we have identified a novel E3 ligase that negatively regulates NLRP3 inflammasome activity. In this review article, we will discuss the regulatory mechanism of NLRP3 inflammasome activity by ubiquitination and the role of NLRP3 inflammasome in the pathogenesis of atherosclerosis and abdominal aortic aneurysm.