Japanese Journal of Complementary and Alternative Medicine
Online ISSN : 1348-7930
Print ISSN : 1348-7922
ISSN-L : 1348-7922
Original Article
Effect of Coix-seed Reactive Derivatives (CRD) on Skin Pigmentation: A Randomized Controlled Trial
Nobutaka SUZUKI , Takuya KAWASHIMA, Hoko KYO, Kazuo UEBABA
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Keywords: Coix lacryma-jobi L. var. ma-yuen Stapf, skin, pigmentation, 紅斑, randomized controlled trial
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2018 Volume 15 Issue 2 Pages 85-90

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Abstract
We evaluated the effects of the extract of Coix-seed Reactive Derivatives (CRD) on female skin pigmentation. Ninety females with facial pigmentation were assigned randomly to 3 groups and CRD (2g/day, 4g/day or placebo) was administrated for 8weeks. We confirmed the safety of CRD, and both the rate of change of facial pigmentation and erythema in 4g/day group decreased significantly (p<0.01). Further studies are needed to define the optimal dose of CRD.
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