Abstract
In this report, we presented the case of a 37-year-old woman who developed facial seborrheic keratosis for about 8 years. Coix-seed Reactive Derivatives(CRD) was administrated orally 4.0 g/day for 20 weeks, and the lesions of seborrheic keratosis improved moderately. Further research is needed to define the optimal dose and duration of CRD intake against these lesions.