Abstract
Objective: Angiotensin I Converting Enzyme was used to study the inhibitory activity of porcine placenta extracts.
Methods: ACE was derived from rabbit lung. Bz-Gly-His-Leu was used as a substrate. Production of hippuric acid was measured by HPLC.
Result: ACE inhibitory activity was measured in a two-fold dilution of porcine placenta extracts. The IC50 of porcine placenta extracts was 95.7 μg. The results of a Lineweaver-Burk plot suggested that porcine placenta extracts exhibited a competitive inhibition.
Conclusion: In this paper, we found that porcine placenta extracts had an anti-ACE activity.
