Japanese Journal of Complementary and Alternative Medicine
Online ISSN : 1348-7930
Print ISSN : 1348-7922
ISSN-L : 1348-7922
Volume 6, Issue 1
Displaying 1-6 of 6 articles from this issue
  • —Recent Topics—
    Takehito MIURA, Kentaro KITADATE, Hiroshi NISHIOKA
    2009 Volume 6 Issue 1 Pages 1-7
    Published: 2009
    Released on J-STAGE: March 12, 2009
    AHCC (Active Hexose Correlated Compound) is an extract from mycelia of Lentinula edodes, a mushroom of the basidiomycetes family, which is cultivated in liquid media in a large tank. It is one of the most frequently used products in complementary and alternative medicine among cancer patients in Japan. Also in recent studies, it has been reported as efficacious in treatment of infectious and inflammatory diseases. AHCC has been proved as safe food by various safety evaluations and drug interaction studies have been conducted. The result of a Phase I trial in healthy volunteers concluded that AHCC is safe as a supplement in clinical practice. The present paper reviews the effects of AHCC in ameliorating the side effects of anti-cancer drugs, in modulating the immune system, in reducing inflammation and in infection prophylaxis.
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Original Article
    2009 Volume 6 Issue 1 Pages 9-15
    Published: 2009
    Released on J-STAGE: March 12, 2009
    Objective: In this study, we evaluated the safety of excessive intake of granular foods containing extract of cultured Lentinula edodes mycelia (L.E.M.) in healthy adult volunteers.
    Methods: Eleven subjects (8 males and 3 females, ages 33.4 ± 9.4) consumed the test foods containing 5,400 mg L.E.M. a day, three times the recommended daily intake, for 4 weeks.
    Results: No adverse effect by excessive intake of test foods was observed in physical and clinical exam. No severe symptom was observed, except for mild gastrointestinal symptom such as soft stool in a subject who has hypersensitive intestine.
    Conclusion: These results suggest that the granular food containing L.E.M. is safe in healthy adults, even if excessive amount up to 5,400 mg a day is consumed.
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  • Rie YAMADA, Kazuhiko AKUZAWA, Changxiao BI, Zhuan LI, Hidetaka SADANAR ...
    2009 Volume 6 Issue 1 Pages 17-25
    Published: 2009
    Released on J-STAGE: March 12, 2009
    Objective: Anti-Human cytomegalovirus (HCMV) activity of Kumazasa (Sasa senanensis Rehder) extract were investigated in the human embryonic lung (HEL) fibroblast cell.
    Method: This study examined the effect of hot water extract from Sasa senanensis Rehder on HCMV replication, viral-specific major immediate early (IE) gene expression, and protein synthesis.
    Results: Treatment of HCMV-infected HEL cells with that Sasa senanensis Rehder extract inhibited the cytopathic effect and viral production in a dose-dependent manner. Further, real-time RT-PCR assay and Western blotting analysis revealed that Sasa senanensis Rehder extract decreased expression of the HCMV IE gene in virus-infected HEL cell.
    Conclusion: These results suggest that Sasa senanensis Rehder extract have anti-HCMV activity by inhibitting of IE gene expression.
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  • Masahito NISHITANI, Yukishige SHIRAICHI, Masaki OHTSUKA, Sayaka AOYAGI ...
    2009 Volume 6 Issue 1 Pages 27-34
    Published: 2009
    Released on J-STAGE: March 12, 2009
    Objective: In the present study, we investigated the effects of enveloping-airflow air conditioner on health maintenance and fatigue in healthy volunteers. The enveloping airflow is that of gently holding the whole room space along the ceiling, wall, and floor.
    Design: In a randomized placebo-controlled crossover trial, 10 healthy women who had feeling cold, stiff shoulder and knee pain very often under air conditioner working, participated in the study. They performed fatigue-inducing desk work for 2 hours, and rested for 30 minutes in the air conditioned room controlled by enveloping airflow or direct airflow.
    Methods: We evaluated subjective sensation by Visual Analogue Scale (VAS), peripheral blood flow by laser-Doppler flowmetry, and body temperature.
    Result: The enveloping airflow prevented hypothermia, increased blood flow, moreover attenuated feeling of cold, knee pain and fatigue, increased sensation of comfort as compared with the direct air flow.
    Conclusion: Enveloping-airflow air conditioner is effective in maintaining health and attenuating fatigue.
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Short Communication
  • Masahiko TEBAKARI, Makiko MATSUI, Fumiya ASUKABE, Michihiko KUMAGAI
    2009 Volume 6 Issue 1 Pages 35-38
    Published: 2009
    Released on J-STAGE: March 12, 2009
    Objective: Angiotensin I Converting Enzyme was used to study the inhibitory activity of porcine placenta extracts.
    Methods: ACE was derived from rabbit lung. Bz-Gly-His-Leu was used as a substrate. Production of hippuric acid was measured by HPLC.
    Result: ACE inhibitory activity was measured in a two-fold dilution of porcine placenta extracts. The IC50 of porcine placenta extracts was 95.7 μg. The results of a Lineweaver-Burk plot suggested that porcine placenta extracts exhibited a competitive inhibition.
    Conclusion: In this paper, we found that porcine placenta extracts had an anti-ACE activity.
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