Experimental Solubilities of Taltirelin in Water, Ethanol, 1-Propanol and 2-Propanol over Temperatures from 273.2 to 323.2 K

Abstract

The solubilities of amorphous form, α-form, and β-form of taltirelin (TTL) in water, ethanol, 1-propanol, and 2-propanol were measured over temperatures ranging from 273.2 to 323.2 K under atmospheric pressure. The experimental data were modelled using the modified Apelblat model. The dissolution enthalpy and entropy of dissolution of TTL polymorphic form in pure solvents were also determined using the van’t Hoff equation. The results reveal that the dissolution of TTL in each solvent is an entropy-driven process.