JOURNAL OF CHEMICAL ENGINEERING OF JAPAN
Print ISSN : 0021-9592
Materials Engineering and Interfacial Phenomena
Crystal Quality Control by Using the Millimeter-Size Tube Type Taylor Vortex Continuous Crystallizer
Yuko YamaguchiWoo-Sik KimHiroshi Takiyama
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2019 年 52 巻 3 号 p. 308-310

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Introduction of a continuous production system to the pharmaceutical field has become realistic. In this field, many kinds of organic crystals with high anisotropic aspect are produced. Hence, crystal morphology affects the pharmaceutical productivity. Therefore, a high production method with crystal morphology improvement currently attracts attention by using a continuous crystallizer. In order to improve the production rate, it is necessary to enhance the crystal growth rate by increasing the mass transfer. The stirring method using Taylor Vortex has been developed in the crystallization research field. The objectives of this study are to design a double-cylinder shaped milli-size crystallizer in order to realize Taylor Vortex, and to evaluate the productivity and crystal morphology. As a result, it was clear that the proposed crystallizer had a productivity about 40 times greater than a conventional batch crystallizer and had a performance which improved the aspect ratio by 59%.

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© 2019 The Society of Chemical Engineers, Japan
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